A „bika drog” rendészeti neurobiológiája

Kulcsszavak: bika drog, drogok neurobiológiája, hatásmechanizmus, szintetikus kannabinoid

Absztrakt

A közelmúltban nagy médiafigyelmet kapott egy új drog, a „bika”, amely arról híresült el, hogy önkívületi állapotba kergeti fogyasztóit, sőt, sokat megöl közülük. A rendészeti lefoglalások kiderítették, hogy a „bika drog” nem más, mint a 4F-MDMB-BICA nevet viselő szintetikus kannabinoid, amelyet Magyarországon 2020 májusában azonosítottak először. Ebben a cikkben arra vállalkozunk, hogy leírjuk a „bika drog” hatásait és hatásmechanizmusát, azonosítsuk egészen közeli „rokonait”, és hazai/nemzetközi körképet nyújtsunk használatának sajátosságairól. A dizájnerdrogok ugyanis rejtve maradnak, amíg valami fel nem hívja rájuk a figyelmet. A cikk rendőrségi szakembereknek szól, akik nem feltétlenül ismerik a drogok neurobiológiáját, ezért a téma vizsgálatát az alapokkal kezdjük, és fokozatosan igyekszünk eljutni azokhoz a szakmai ismeretekhez, amelyeket nem nélkülözhet az, aki bármilyen okból tájékozott szeretne lenni a „bika drog” témájában.

Hivatkozások

Banister, S. D., Longworth, M., Kevin, R., Sachdev, S., Santiago, M., Stuart, J., Mack, J. B, C., Glass, M., McGregor, I. S., Connor, M. & Kassiou, M. (2016). Pharmacology of Valinate and tert-Leucinate Synthetic Cannabinoids 5F-AMBICA, 5F-AMB, 5F-ADB, AMB-FUBINACA, MDMB-FUBINACA, MDMB-CHMICA, and Their Analogues. ACS Chemical Neuroscience, 7(9), 1241–1254. https://doi.org/10.1021/acschemneuro.6b00137

Barna, I., Till, I. & Haller, J. (2009). Blood, adipose tissue and brain levels of the cannabinoid ligands WIN-55,212 and SR-141716A after their intraperitoneal injection in mice: compound-specific and area-specific distribution within the brain. European Neuropsychopharmacology, 19(8), 533-41. https://doi.org/10.1016/j.euroneuro.2009.02.001

Beckett, G. H. & Wright, C. R. A. (1875). Action of the organic acids and their anhydrides on the natural alkaloids. Part II. J. Journal of the American Chemical Society, 28,15-26. https://doi.org/10.1039/JS8752800312

Bortolato, M., Mangieri, R. A., Fu, J., Kim, J. H., Arguello, O., Duranti, A., Tontini, A., Mor, M., Tarzia, G. & Piomelli, D. (2007). Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress. Biological Psychiatry, 62(10), 1103-1110. https://doi.org/10.1016/j.biopsych.2006.12.001

Cohen, P.J. (2009). Medical marijuana: the conflict between scientific evidence and political ideology. Part one of two. Journal of Pain & Palliative Care Pharmacotherapy, 23(1), 4-25. https://doi.org/10.1080/15360280902727973

Compton, D., Dewey, W. & Martin, B. (1990). Cannabis dependence and tolerance production. Advances in Alcohol and Substance Abuse, 9(1-2),129-147. https://doi.org/10.1300/J251v09n01_08

De Vries, T. J., Shaham, Y., Homberg, J. R, Crombag, H., Schuurman, K., Dieben, J., Vanderschuren, L. J. & Schoffelmeer, A.N. (2001). A cannabinoid mechanism in relapse to cocaine seeking. Nature Medicine, 7(10), 1151-1154. https://doi.org/10.1038/nm1001-1151

De Vries, T. J., Homberg, J. R., Binnekade, R., Raasø, H. & Schoffelmeer, A. N. M. (2003). Cannabinoid modulation of the reinforcing and motivational properties of heroin and heroin-associated cues in rats. Psychopharmacology, 168(1-2), 164-169. https://doi.org/10.1007/s00213-003-1422-1

Devane, W. A., Dysarz, 3rd. F. A., Johnson, M. R., Melvin, L. S. & Howlett, A. C. (1988): Determination and characterization of a cannabinoid receptor in rat brain. Molecular Pharmacology, 34(5), 605-613.

Devane, W. A., Hanus, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A. & Mechoulam, R. (1992). Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science, 258(5090), 1946-1949. https://doi.org/10.1126/science.1470919

Freund, T. F., Katona, I. & Piomelli, D. (2003). Role of endogenous cannabinoids in synaptic signaling. Physiological Review, 83(3), 1017-1066. https://doi.org/10.1152/physrev.00004.2003

Fusar-Poli, P., Crippa, J. A., Bhattacharyya, S., Borgwardt, S. J., Allen, P., Martin-Santos, R., Seal, M., Surguladze, S. A., O’Carrol, C., Atakan, Z., Zuardi, A.W. & McGuire, P. K. (2009). Distinct effects of {delta}9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing. Archive of General Psychiatry, 66(1), 95-105. https://doi.org/10.1001/archgenpsychiatry.2008.519

Grinspoon, L., Bakalar, J.B. (1998). The use of cannabis as a mood stabilizer in bipolar disorder: anecdotal evidence and the need for clinical research. Journal of Psychoactive Drugs, 30(2),171-177. https://doi.org/10.1080/02791072.1998.10399687

Haller, J., Bakos, N., Szirmay, M., Ledent, C. & Freund, T. F. (2002). The effects of genetic and pharmacological blockade of the CB1 cannabinoid receptor on anxiety. European Journal of Neuroscience, 16(7), 1395-1398. https://doi.org/10.1046/j.1460-9568.2002.02192.x

Haller, J., Barna, I., Barsvari, B., Gyimesi Pelczer, K., Yasar, S., Panlilio, L.V. & Goldberg, S. (2009). Interactions between environmental aversiveness and the anxiolytic effects of enhanced cannabinoid signaling by FAAH inhibition in rats. Psychopharmacology, 204, 607-616. https://doi.org/10.1007/s00213-009-1494-7

Krotulski, A. J., Mohr, A. L. A., Kacinko, S. L., Fogarty, M. F., Shuda, S. A., Diamond, F. X., Kinney, W. A., Menendez, M. J. & Logan, B. K. (2019). 4F-MDMB-BINACA: A New Synthetic Cannabinoid Widely Implicated in Forensic Casework. Journal of Forensic Sciences, 64(5), 1451–1461. https://doi.org/10.1111/1556-4029.14101

Long, J. Z., Li, W., Booker, L., Burston, J. J., Kinsey, S. G., Schlosburg, J. E., Pavón, F. J., Serrano, A. M., Selley, D. E., Parsons, L. H., Lichtman, A. H., Cravatt, B. F. (2009). Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nature Chemical Biology, 5(1), 37–44. https://doi.org/10.1038/nchembio.129

Martin, B. R., Balster, R. L., Razdan, R. K., Harris, L.S. & Dewey, W. L. (1981). Behavioral comparisons of the stereoisomers of tetrahydrocannabinols. Life Sciences, 29(6),565-74. https://doi.org/10.1016/0024-3205(81)90434-3

Martin, M., Ledent, C., Parmentier, M., Maldonado, R. & Valverde, O. (2002). Involvement of CB1 cannabinoid receptors in emotional behaviour. Psychopharmacology, 159(4), 379–387. https://doi.org/10.1007/s00213-001-0946-5

McPartland, J. M., Glass, M. & Pertwee, R. G. (2007). Meta-analysis of cannabinoid ligand binding affinity and receptor distribution: interspecies differences. British Journal of Pharmacology, 152(5), 583–593. https://doi.org/10.1038/sj.bjp.0707399

Merritt, L. L., Martin, B. R., Walters, C., Lichtman, A. H. & Damaj, M. I. (2008). The endogenous cannabinoid system modulates nicotine reward and dependence Journal of Pharmacology and Experimental Therapeutics, 326(2), 483-492. https://doi.org/10.1124/jpet.108.138321

Napoletano, F., Schifano, F., Corkery, J. M., Guirguis, A., Arillotta, D., Zangani, C., Vento, A. (2020). The Psychonauts’ World of Cognitive Enhancers. Frontiers in Psychiatry, 11, 546796. https://doi.org/10.3389/fpsyt.2020.546796

Orsolini, L., Papanti, G. D., Francesconi, G., Schifano, F. (2015). Mind navigators of chemicals’ experimenters? A Web-based Descript E-psychonauts. Cyberpsychology, Behavior And Social Networking, 18(5), 296–300. https://doi.org/10.1089/cyber.2014.0486

Racz, I., Bilkei-Gorzo, A, Toth, Z. E., Michel, K., Palkovits, M. & Zimmer, A. (2003): A critical role for the cannabinoid CB1 receptors in alcohol dependence and stress-stimulated ethanol drinking. The Journal of Neuroscience, 23(6), 2453-2458. https://doi.org/10.1523/JNEUROSCI.23-06-02453.2003

Schäper, J. (2016). Wirkstoffgehalte und inhomogene Verteilung des Wirkstoffs MDMBCHMICA in Kräutermischungen. Toxichem Krimtech, 83(2), 112–114. https://www.gtfch.org/cms/images/stories/media/tk/tk83_2/Schaeper_et_al_2016.pdf

Scherma M, Panlilio LV, Fadda P, Fattore L, Gamaleddin I, Le Foll B, Justinová Z, Mikics E, Haller, J., Medalie, J., Stroik, J., Barnes, C., Yasar, S., Tanda, G., Piomelli, D., Fratta, W. & Goldberg, S. R. (2008). Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3’-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in rats. Journal of Pharmacology and Experimental Therapeutics, 327(2), 482-90. https://doi.org/10.1124/jpet.108.142224

Smith, C. G., Almirez, R. G., Berenberg, J. & Asch, R. H. (1983). Tolerance develops to the disruptive effects of delta 9-tetrahydrocannabinol on primate menstrual cycle. Science, 219(4591), 1453-1455. https://doi.org/10.1126/science.6298938

Stansfield, C. R, Somerville, R. F, Hassan, V. R, Kolbe, E., Partington, H. K, Walsh, K. A. J., Johnson, C. S. (2020). Effects of external influences on synthetic cannabinoid trends in New Zealand, 2014 to 2020. Forensic Science International, 316, 110485. https://doi.org/10.1016/j.forsciint.2020.110485

Tripathi, R. K. P. (2020). A perspective review on fatty acid amide hydrolase (FAAH) inhibitors as potential therapeutic agents. European Journal of Medicinal Chemistry, 15(188), 111953. https://doi.org/10.1016/j.ejmech.2019.111953

Ware, M.A., St Arnaud-Trempe, E. (2010). The abuse potential of the synthetic cannabinoid nabilone. Addiction, 105(3), 494-503. https://doi.org/10.1111/j.1360-0443.2009.02776.x

Watanabe, K., Matsunaga, T., Nakamura, S., Kimura, T., Ho, I. K., Yoshimura, H. & Yamamoto, I. (1999). Pharmacological effects in mice of anandamide and its related fatty acid ethanolamides, and enhancement of cataleptogenic effect of anandamide by phenylmethylsulfonyl fluoride. Biological and Pharmaceutical Bulletin, 22(4), 366-370. https://doi.org/10.1248/bpb.22.366

Wilson, R. I., Nicoll, R. A. (2001). Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses. Nature, 410(6828), 588–592. https://doi.org/10.1038/35069076

Yin, S. (2019). Adolescents and Drug Abuse: 21st Century Synthetic Substances. Clinical Pediatric Emergency Medicine, 20(1), 17–24. https://doi.org/10.1016/j.cpem.2019.03.003

Zanettini, C., Panlilio, L.V., Alicki, M., Goldberg, S. R., Haller, J. & Yasar, S. (2011). Effects of endocannabinoid system modulation on cognitive and emotional behavior. Frontiers in Behavioral Neuroscience, 5, 57. https://doi.org/10.3389/fnbeh.2011.00057

Megjelent
2021-04-26
Hogyan kell idézni
Rompos Éva, BaráthN. E., BellavicsZ. M., LohnerK., & HallerJ. (2021). A „bika drog” rendészeti neurobiológiája. Belügyi Szemle , 69(4), 531-552. https://doi.org/10.38146/BSZ.2021.4.1
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