Role of transglutaminases in dermatitis herpetiformis

Abstract

In this review article, after a short introduction, the authors present the pathogenesis and pathomechanism of dermatitis herpetiformis from the perspective of the transglutaminase enzyme family. According to our current knowledge, these
isoenzymes consist of nine members in humans, and four of them play a role in the development of the disease. The main autoantigen is probably epidermal transglutaminase, but the role of other isozymes cannot be neglected either.
The mechanism of the development of gluten-sensitive enteropathy is presented, followed by the theory of formation of IgA-epidermal transglutaminase immune complexes. The article also briefly covers the associated disorders of
the blood coagulation system and neurological conditions.