Early gut microbiota development and catch-up weight gain in full-term small for gestational age infants in the first year of life

Magdalena Durda-Masny; Joanna Ciomborowska-Basheer; Norbert Grundmann; Marta Szymankiewicz-Breborowicz; Monika Englert-Golon; Jan Mazela; Katarzyna Moranska; Izabela Makalowska; Wojciech Makalowski; Anita Szwed

Magdalena Durda-Masny Adam Mickiewicz University, Faculty of Biology, Institute of Human Biology and Evolution, Poznan, Poland
Joanna Ciomborowska-Basheer Adam Mickiewicz University, Faculty of Biology, Institute of Human Biology and Evolution, Poznan, Poland; Adam Mickiewicz University, Faculty of Biology, Laboratory of Nature Education and Conservation, Poznan, Poland
Norbert Grundmann University of Munster, Faculty of Medicine, Institute of Bioinformatics, Munster, Germany
Marta Szymankiewicz-Breborowicz Poznan University of Medical Sciences, Department of Neonatology, Poznan, Poland
Monika Englert-Golon Poznan University of Medical Sciences, Department of Gynecology, Obstetrics and Gynecological Oncology, Poznan, Poland
Jan Mazela Poznan University of Medical Sciences, Department of Neonatology, Poznan, Poland
Katarzyna Moranska Adam Mickiewicz University, Faculty of Biology, Institute of Human Biology and Evolution, Poznan, Poland
Izabela Makalowska Adam Mickiewicz University, Faculty of Biology, Institute of Human Biology and Evolution, Poznan, Poland
Wojciech Makalowski University of Munster, Faculty of Medicine, Institute of Bioinformatics, Munster, Germany; Adam Mickiewicz University, Faculty of Biology, Department of Genetics, Poznan, Poland
Anita Szwed Adam Mickiewicz University, Faculty of Biology, Institute of Human Biology and Evolution, Poznan, Poland

Absztrakt

Background: The gut microbiota undergoes dynamic changes during infancy, a period that coincides with intensive early growth and metabolic development.

Objective: This study aimed to assess gut microbiota colonization patterns in full-term small for gestational age (SGA) infants with catch-up weight gain during the first year of life.

Subjects and methods: The longitudinal cohort study included 19 full-term SGA infants and 46 full-term infants born appropriate for gestational age (AGA). Stool samples and body weight measurements were collected at several points throughout the first year of life. Gut microbiota composition was assessed using 16S rRNA gene sequencing. Microbial composition and diversity across developmental stages were evaluated using alpha diversity, beta diversity, and taxa abundance analyses. The relationship between the rate of weight gain and the pace of gut microbiota maturation was also examined.

Results: SGA infants demonstrated higher alpha diversity than AGA infants at most time points. In the SGA group, the Shannon index, reflecting gut microbiota maturation, was positively associated with the rate of body weight gain over time (p=0.015), whereas no such association was observed in AGA infants. Genera characteristic of SGA group included Citrobacter, Staphylococcus, Blautia, Veillonella, Klebsiella and Clostridium XIVa.

Conclusions: Overall, SGA infants exhibited a distinct gut microbiota profile with higher alpha diversity compared with AGA peers. In this group, a more mature microbiota was associated with faster weight gain and a greater abundance of short-chain fatty acid-producing and obesity-associated bacteria, suggesting that early microbial development may contribute to the risk of overweight and obesity later in life.

Hivatkozások

References: None.