Preparation and drug profile analysis of crosslinked hydrogels based on hyaluronic acid for dental application

Esetismertetés

Abstract

Exploiting the biodegradability and biocompatibility of hyaluronic acid, the hyaluronic acid-based systems are increasingly used in dentistry also. To achieve the targeted drug delivery one of the most widely used method of cross-linking the biopolymers. The purpose of this work was to produce and characterizes hyaluronic acid-based systems, which can also be used in dentistry as drug delivery system. To synthesize the different ratios (25, 50, 75, 100%) cross-linked structure hyaluronic acid sodium salt and 2,2’(ethylenedioxy) bis (ethylamine) was applied in a condensation reaction using carbodiimide. The sizes of the particles were determined by dynamic light scattering (DLS) measurements. On the basis of the results obtained that each of four kinds of modified material are made up three different particle sizes and when the rate of change was increased, the particle size was decreased. This could be compared to results obtained under transmission electron microscope (TEM) investigations. To characterize the release behavior of cross-linked derivatives of hyaluronic acid, photometric measurement technique was applied using methylene blue as a model compound. Our results supported that the proportion of cross-linking was increased, the drug release rate was increased also, which may be the basis for further experiments in the development of a new injectable drug substance issuer system.